As scientists at Oxford’s Jenner Institute prepare for mass clinical trials, new tests show their COVID19 vaccine is effective in monkeys

Scientists at Oxford university’s Jenner Institute, have scheduled tests of their new Coronavirus vaccine involving more than 6,000 people by the end of May, hoping to show not only that it is safe, but also that it works.

And recent news suggests that it might.

Scientists at the National Institutes of Health’s Rocky Mountain Laboratory in Montana last month inoculated six rhesus macaque monkeys with single doses of the Oxford vaccine.

The animals were then exposed to heavy quantities of the virus that is causing the pandemic — exposure that had consistently sickened other monkeys in the lab.

But more than 28 days later all six were healthy.

Immunity in monkeys is no guarantee that a vaccine will provide the same degree of protection for humans. But it is encouraging.

The institute’s effort against the coronavirus uses a technology that centres on altering the genetic code of a familiar virus.

A classic vaccine uses a weakened version of a virus to trigger an immune response. But in the technology that the institute is using, a different virus is modified first to neutralize its effects and then to make it mimic the one scientists seek to stop — in this case, the virus that causes Covid-19.

Injected into the body, the harmless impostor can induce the immune system to fight and kill the targeted virus, providing protection.

Donors are currently spending tens of millions of dollars to start the manufacturing process at facilities in Britain and the Netherlands even before the vaccine is proven to work.

There is talk of one million doses of vaccine ready by September. Most analysts recognize, that measures to open the economy will already need to be underway by then.

As I write this AstraZeneca has just announced it will manufacture Oxford Uni’s vaccine ChAdOx1 nCoV-19.

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UK cabinet discuss lifting all restrictions by June 13

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With new cases of  COVID-19 now flattening, transmission rates (R) are at 1 or below in the UK. This could be the moment to begin loosening suppression measures. But the question is when to start.

The UK cabinet is split on the decision, reports the FT.

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The split centres on how low the reproduction rate of the virus — known as its R number — should be before the lockdown starts to be unwound. Government officials confirm that Mr Gove and Mr Sunak believe that if the R number is sustainably below 1 — where the number of new infections is no longer rising — then restrictions can begin to be lifted.

The Sunday Times, which first reported the tensions, quoted Mr Gove as telling colleagues that “we need to run this hot”, so that new virus cases — and deaths — would continue but within the capacity of the NHS to cope.

But Mr Hancock wants the R number close to zero before beginning to reopen the economy, arguing that Britain cannot afford another damaging peak.

The government’s current lack of testing capacity is a key issue. Although Mr Gove said on Sunday that the government was “on course to be able to test 100,000 a day by the end of the month” it currently has capacity for only 38,000.

Testing and tracing of contacts are a key part of any exit strategy.

One government adviser said Mr Johnson had a huge decision to make. “Do you take it to zero or do you start to end the lockdown? It’s the biggest policy issue facing the country.”

When it does come time to remove restrictions. a paper by UCL could point the way. It suggests a traffic light system to stagger the lifting of restrictions.:

Red (slight easing of restrictions but with strict caution while risk is still high), Amber (conditions improve but we still need to be careful) and Green (when medical experts give the all clear). The authors suggest lockdown could be eased from early May, with the final stages in June 13.

Traffic light system for a lockdown exit strategy:

Red phase (May 1)

  • Deliberately called red to ensure people think before they act
  • Visiting friends and family allowed, but no visits to grandparents
  • More – but not all – types of shops could open and they would have to exercise strict social distancing, as most supermarkets do now.
  • Travel should still be discouraged and many international flights banned.

Amber phase (May 22)

  • Private car travel no longer limited
  • In order to minimise pressure on public transport, and crowds, there would have to be attempts to vary the rush-hour, with different opening and closing times.
  • Wearing masks and disposable gloves could be compulsory when using public transport.
  • Restaurants could reopen but with strict seating demarcations, to uphold social distancing.
  • Home working advised for those that can.

Green phase (June 13)

  • Public fully released from lockdown if health experts allowed it
  • Sporting events or mass gatherings could take place, and places of worship reopen.
  • International travel could return to normal.

 

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This chart shows the UK government is nowhere near the level of testing it promised

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As we pass the peak of new cases of COViD19 in the UK, thoughts trun to when – and how – the lockdown can be lifted.

The key to any ordered resumption to normal life is testing.

The New York Times writes this morning:

“Have we slowed the spread of the coronavirus? Are we past the peak? When can we safely ease restrictions? How can we head off a second wave of infections? The answers all depend on swift, accurate, widespread and readily available testing, both for active infections and for the antibodies they leave behind. Without it, officials trying to grapple with the pandemic are flying blind.”

Furthr’s research suggests that the UK is nowhere near the level of testing promised by the government.The government memorably promised 100,00 tests a day by the end of April, which is under two weeks away.

Current rates are under 10,0000 tests a day and not rising anytime soon (see trend-line on chart). That means the government has already missed its interim target of 25,000 test a day by mid-April.

Any organised plan to relax restrictions would depend on thorough testing.

In the US business executives told President Trump on a conference call that much wider testing is needed before reopening the economy. They said they were worried about huge lawsuits if workers were called back too soon and became infected on the job.

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UK exit strategy: Furthr’s COVID-19 heatmap showing how the disease is spreading is in BETA

Screenshot 2020-04-14 at 12.07.17Data from John Hopkins suggest the UK may have hit a peak of new cases of COVID-19 last week, on Thursday April 10.

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If that is true – and it takes 12 consecutive days of a downward trend to prove we are past the worst point – then thoughts will turn to act three in this tragedy: how the UK gradually starts to lift restrictions.

With that in mind, Furthr are working on a heat map of the UK showing where most of the COVID-19 cases are. (See above) We are also adding a timeline to show how the disease is progressing.

 

 

 

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UK exit strategy: These charts explain why 12 year olds from Bath will be the first to be released from COVID-19 lockdown

1_bathghostThe government will relax lockdown restrictions according to age and geography, Neil Ferguson revealed this morning on the BBC.

What does that look like?

Here at Furthr industries we have run our slide rule over the UK’s new cases and, based on the idea that we are tracking to Italy, predict lockdown measures could start to be released May 23rd.  (It is worth noting that the city of Wuhan, where the COVID-19 outbreak began, lifted its lockdown seven weeks from its peak of new cases.)

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Next we can take a look at how ages are affected by COVID-19 and see clearly which age groups would be released first. 

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Finally we can look at  the geographic spread of cases across the UK.Screenshot 2020-04-10 at 11.23.26

 

What have we learned? If you are a twelve year old from Bath, it is likely restrictions on your movement will be lifted first. Good news for my twin daughters I guess.

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These charts show the NHS now has enough hospital beds for this weeks’ COVID-19 surge

NINTCHDBPICT000473813805This morning I received a text from my local doctor’s explaining they would be open this weekend “in support of the COVID-19 pandemic and the wider NHS framework.”

As our models have shown, it’s likely that new cases of COVID-19 will peak, starting this weekend.

At the same time, a study from Washington State University has predicted a dire death toll for the UK .

At Furthr we do not want to underplay the severity of the crisis we all face. Nor would we wish to diminish how underprepared the NHS were when the crisis first struck. But since then, things have changed, and there is now some reassuring data regarding how prepared the NHS are.

At time of writing, cumulative cases of COVID-19 in the UK is at 61474, according to John Hopkins University.

Screenshot 2020-04-09 at 08.35.01

 

 

Of those cases we can expect 14 per cent to need to go to hospital. That is 8606 people in hospital.

0Right now, there are 33,000 beds available for COVID-19 patients, according to The Guardian.

So in other words, even if new cases new entrants to hospital were to double, there would still be enough NHS beds to accommodate them.

 

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These charts show what to expect in the next ten days

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When will lockdown be over? It’s a question we’d all like the answer to, and of course, we do not know.

However, it is possible to make an estimation.

Researchers at the FT  suggest we in the UK are on a similar trajectory to Italy, who went into lockdown weeks before the UK. Let”s compare the two on a timeline to see what we in the UK have in store.

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Italy’s lockdown started March 9, 2020. After that new cases – a key metric when measuring  the progress of the disease – peaked on March 27, 18 days after the lockdown began. (Daily deaths in Italy and Spain peaked around 23-24 days after lockdown started.  See chart below.Screenshot 2020-04-06 at 21.39.32

Here in the UK our lockdown started March 24, 2020. As of today, we have been in lockdown for 14 days. If we were to map to Italy’s experience, we could expect to hit peak new cases in five days, Saturday April 11.  (UK deaths could peak with deaths in 7-10 days, the middle of next week.)
As the UK runs into a hot zone of illness and death from Corvid-19, Boris Johnson’s sickness could not have come at a worst time. We wish him  a speedy recovery. (Insiders say that if Boris goes onto a ventilator, UK will require new Prime Minister.)

When will it be over?

Finally we could hazard a guess, based on Italy’s data, at what point we could start to return to a level of new cases that were “manageable” ie the health system could cope with them. At that point some restrictions could be relaxed as we enter the phase of containment known as “the dance.” see below.
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Based on an extrapolation of Italian data we see that lockdown conditions could end May 11, if the rate of decline in new cases stays as it is now. If UK continues to track to Italy’s trends we can expect restrictions to be eased May 23rd. Here’s what that looks like.
lockdown2
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Google searches for “Why can’t I smell?” could predict outbreaks of new cases of Corona Virus

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Researchers in the US have observed an interesting phenomena.

Google searches for “Why can’t I smell?” appear to be predicting outbreaks of new cases of Corona Virus.

There is strong evidence that anosmia, or loss of smell, is a symptom of Covid-19, with some estimates suggesting that 30-60 percent of people with the disease experience this symptom.

Google searches for the phrase “loss of smell” align closely with the number of positive cases of coronavirus. See below.

Screenshot 2020-04-06 at 10.55.42

Searches for “non sento odori” (“I can’t smell”) spiked in Italy as the coronavirus outbreak spread — but before a report was released identifying the possible symptom.

Screenshot 2020-04-06 at 11.03.20

 

You can test the hypothesis for yourself.

If you check Google Trends in the UK to see volume of searches for “I can’t smell” it looks like this.

Screenshot 2020-04-06 at 10.15.27

Now take a look at the record of new cases in the UK, collected by John Hopkins University.

Screenshot 2020-04-06 at 10.15.42

Researchers have pointed out that localized Google searches could be a useful marker for the next outbreak of cases of Corona Virus, especially given the five day delay before symptoms emerge.

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Here’s the UK Google and new case data combined.

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